The San Francisco 49ers have announced their 2025 regular season schedule along with the opponents and date ranges for the team's three preseason games.
The 49ers will face the NFC South and AFC South in cross-divisional play, while continuing to battle their NFC West opponents twice a year. San Francisco will also host the Chicago Bears (Week 17) and visit the New York Giants (Week 9) and Cleveland Browns (Week 13). The Niners open the regular season on the road as they visit the Seattle Seahawks. The team is scheduled to play in five prime time games during the regular season, including three at home, with two on Monday night (Week 12 vs. Carolina & Week 16 at Indianapolis), two on Sunday night (Week 7 vs. Atlanta & Week 17 vs. Chicago) and one on Thursday night (Week 5 at Los Angeles Rams).
A Closer Look at the 2025 Schedule
- San Francisco will open the regular season on the road (at Seattle) for the fourth time in five seasons and for the first time since visiting the Pittsburgh Steelers in Week 1 of the 2023 season.
- The 49ers open the season on the road against an NFC West opponent for the first time since the 2010 season when they visited Seattle in Week 1.
- The Niners open the season against an NFC West opponent for the first time since the 2020 season when they hosted the Arizona Cardinals in Week 1.
- The Niners will make back-to-back road trips to begin the season for the first time since the 2023 season [Week 1 at Pit. (9/10/23) & Week 2 at LAR (9/17/23)].
- San Francisco will play in at least five prime time games for the fourth-consecutive season.
- The 49ers close the regular season at home (Week 18 vs. Seattle) for the third time in five seasons.
Week 1 Sunday, September 7 at Seattle 1:05 p.m. PT on FOX
- San Francisco opens the season against Seattle for the third time in series history and for the first time since the 2011 season [W, 33-17 vs. Sea. (9/11/11)].
- The 49ers are 23-31 all-time against the Seahawks, including an 11-17 record on the road.
- The Niners look for their fourth-consecutive victory at Lumen Field, which would mark the longest road winning streak against the Seahawks in series history.
Week 2 Sunday, September 14 at New Orleans 10:00 a.m. PT on FOX
- San Francisco owns the overall series record against New Orleans 50-27-2, including a 26-15 record on the road.
- The Niners have won four of the previous seven regular season matchups between the two teams, including the last time they met in the 2022 season [W, 13-0 vs. NO (11/27/22)].
- The 49ers travel to New Orleans for the first time since the 2020 season and look to earn their first win at Caesars Superdome since their 48-46 victory against the Saints in 2019.
Week 3 Sunday, September 21 vs. Arizona 1:25 p.m. PT on FOX
- San Francisco owns the overall series record vs. Arizona 36-31, including a 20-15 record at home.
- The Niners have won two of their last three matchups against the Cardinals at Levi's Stadium.
- The 49ers look for their first home victory against the Cardinals since the 2023 season [W, 35-16 vs. Arz. (10/1/23)].
- San Francisco looks for their fourth-consecutive victory in the home opener.
Week 4 Sunday, September 28 vs. Jacksonville 1:05 p.m. PT on FOX
- San Francisco leads the all-time series against Jacksonville, 5-2, including a 2-0 record at home.
- The 49ers have won each of the previous five matchups against the Jaguars.
- San Francisco hosts Jacksonville at Levi's Stadium for the first time since the 2017 season, when they defeated the Jaguars 44-33 [vs. Jax. (12/24/17)].
Week 5 Thursday, October 2 at Los Angeles Rams 5:15 p.m. PT on Prime Video
- San Francisco owns the overall series record vs. the Los Angeles Rams, 78-71-3, including a 40-35-1 record on the road.
- The Niners will face the Rams on Thursday Night Football for the fifth time in series history and for the first time in consecutive seasons.
- The 49ers will play at SoFi Stadium on TNF for the first time.
- The 49ers have won seven of the last nine regular season matchups on the road against the Rams since their return to Los Angeles in 2016.
Week 6 Sunday, October 12 at Tampa Bay 10:00 a.m. PT on CBS
- San Francisco leads the all-time series against Tampa Bay 21-7, including a 7-4 record on the road.
- San Francisco will play Tampa Bay in the regular season for the fourth-consecutive season for the first time since the 1977-1980 seasons.
- The 49ers visit the Buccaneers in consecutive seasons for the first time since the 2018 and 2019 seasons and look for their fifth-consecutive victory against the team.
- The Niners have won seven of the last 10 meetings between the two teams.
Week 7 Sunday, October 19 vs. Atlanta 5:20 p.m. PT on NBC
- San Francisco leads the all-time series against Atlanta, 48-33-1, including a 29-12 record at home.
- It marks the first time the 49ers have hosted the Falcons since the 2021 season [W, 31-13 vs. Atl. (12/19/21)].
- The 49ers face the Falcons on Sunday Night Football for the second time in series history (12/19/82).
- The 49ers are 4-2 against the Falcons in prime time, with their most recent victory coming in the 2013 season [W, 34-24 vs. Atl. (12/23/13)].
- The Niners have won three of their previous five home games against the Falcons.
Week 8 Sunday, October 26 at Houston 10:00 a.m. PT on FOX
- San Francisco is 4-1 all-time against the Houston Texans, including a 1-1 record on the road.
- The 49ers look to earn their fourth-consecutive victory against the Texans and the first since defeating the Texans 23-7 at Levi's Stadium on January 2, 2022.
- The Niners will visit NRG Stadium for the first time since the 2017 season when they earned a 26-16 victory against the Texans [at Hou. (12/10/17)].
Week 9 Sunday, November 2 at New York Giants 10:00 a.m. PT on CBS
- San Francisco is 22-21 all-time against the New York Giants with a 9-11 record on the road.
- The Niners will face the Giants in the regular season for the first time since 2023 [W, 30-12 vs. NYG (9/21/23)].
- The 49ers look to earn their third-consecutive overall victory against the Giants and their second-consecutive road win after beating the Giants on their last trip to New York in 2020, 36-9 [at NYG (9/27/20)].
Week 10 Sunday, November 9 vs. Los Angeles Rams 1:25 p.m. PT on FOX
- San Francisco owns a 38-36-2 record at home against the Los Angeles Rams.
- The 49ers are 9-3 in the previous 12 regular season matchups between the two teams.
- The Niners have won four of their last six home games against the Rams.
Week 11 Sunday, November 16 at Arizona 1:05 p.m. PT on FOX
- San Francisco is 16-16 when on the road against Arizona.
- The Niners have won four of the previous six road games against the Cardinals.
- San Francisco looks to earn a victory at State Farm Stadium for the first time since their 45-29 victory against the team in 2023 [at Arz. (12/17/23)].
Week 12 Monday, November 24 vs. Carolina 5:15 p.m. PT on ESPN
- San Francisco is 10-13 in the all-time series vs. Carolina, including a 4-7 mark at home.
- The 49ers will host the Panthers at Levi's Stadium for the first time since the 2019 season [W, 51-13 vs. Car. (10/27/19)].
- The Niners will face the Panthers on Monday Night Football for the second time in series history [W, 34-21 at Car. (9/29/97)].
- The 49ers are 2-0 when facing the Panthers in prime time.
- San Francisco's 53 wins on Monday Night Football are the second-most wins on MNF in NFL history.
Week 13 Sunday, November 30 at Cleveland 10:00 a.m. PT on CBS
- San Francisco is 8-13 all-time against Cleveland and 2-8 on the road.
- The 49ers are looking for their first road win against Cleveland since the 1984 season, when they defeated the Browns 41-7 [at Cle. (11/11/84)].
- The two teams have split the previous four meetings.
Week 14 Sunday, December 7 BYE
- This marks the first time since BYE Weeks were introduced in 1990 that the 49ers have had their BYE Week in Week 14.
Week 15 Sunday, December 14 vs. Tennessee 1:25 p.m. PT on FOX
- San Francisco is 9-6 in the all-time series vs. Tennessee, including a 4-3 record at home.
- The Niners have won six of the previous 10 matchups against the Titans.
- The 49ers host the Titans at Levi's Stadium for the second time and the first since the 2017 season [W, 25-23 vs. Ten. (12/17/17)].
- San Francisco is looking for their fourth-consecutive victory coming off the BYE Week.
Week 16 Monday, December 22 at Indianapolis 5:15 p.m. PT on ESPN
- San Francisco is 18-27 all-time against Indianapolis, including a 7-15 mark on the road.
- The Niners will face the Colts in prime time for the second time in franchise history and the first since October 24, 2021.
- San Francisco will travel to Indianapolis for the first time since the 2017 season and look to earn their first road victory since defeating the Colts, 40-21, at Lucas Oil Stadium (11/25/01).
Week 17 Sunday, December 28 vs. Chicago 5:20 p.m. PT on NBC
- San Francisco leads the all-time series vs. Chicago, 36-33-1, including a 23-14 mark at home.
- It marks the first time the 49ers have hosted the Bears in consecutive regular seasons since the 1978-79 seasons.
- The 49ers have won six of their previous 10 matchups with the Bears.
- The Niners will play in prime time games in back-to-back weeks for the first time since Weeks 10-11 of the 2022 season.
Week 18 Saturday or Sunday, January 3 or 4 vs. Seattle
- San Francisco owns a 12-14 record at home against Seattle.
- The Niners have won five of the previous 10 regular season matchups against the Seahawks, including two of the last three home matchups.
- The 49ers and Seahawks will meet in the final week of the regular season for the fifth time in series history.
This season, "flexible scheduling" for Sunday Night Football may be used up to twice between Weeks 5-10, and in the NFL's discretion during Weeks 11-17; for Monday Night Football at the NFL's discretion in Weeks 12-17; and for Thursday Night Football it may be used up to twice between Weeks 13-17. During these Flex Scheduling Windows, the games initially scheduled for Sunday Night Football (on NBC), Monday Night Football (on ESPN or ABC), and Thursday Night Football (on Amazon Prime Video) are tentatively scheduled and subject to change. Only Sunday afternoon games (or those listed as TBD) are eligible to be moved to Sunday night, Monday night, or Thursday Night, in which case the initially scheduled Thursday/Sunday/Monday night game would be moved to Sunday afternoon. Sunday afternoon games may also be moved between 1:00 p.m. and 4:05 p.m. or 4:25 p.m. ET.
As in prior seasons, for Week 18, the final weekend of the season, the scheduling of the Saturday, Sunday afternoon, and the Sunday night games is not assigned. In Week 18, two games will be played on Saturday (4:30 p.m. ET and 8 p.m. ET) with the remainder to be played on Sunday afternoon (1 p.m. ET and 4:25 p.m. ET) and one matchup to be played on Sunday night (8:20 p.m. ET).
Specific dates, start times, and networks for Week 18 matchups will be determined and announced following the conclusion of Week 17. For more information about NFL Flexible Scheduling, please visithttps://www.nfl.com/schedules/flexible-scheduling-procedures.
49ers Season Tickets
Fans interested in purchasing season tickets can sign up for more information or schedule an appointment at49ers.com/seasontickets. For immediate assistance, please [email protected]. The 49ers prefer Visa for all ticket purchases.
49ers Premium Luxury Suites
Fans interested in reserving a premium suite to a 49ers home game can sign up for more information or purchase directly at49erssuites.com. For immediate assistance, please [email protected]. The 49ers prefer Visa for all ticket purchases.
Levi's Stadium Group Tickets
Fans planning a group outing for 10+ to a 49ers home game can get more information at49ers.com/tickets/group-tickets. For immediate assistance, please [email protected]. The 49ers prefer Visa for all ticket purchases.
49ers Single Game Tickets
Fans interested in purchasing single game tickets to a 49ers home game should visit49ers.com/tickets/single-gameto purchase. Ticket prices and availability are subject to demand. The 49ers prefer Visa for all ticket purchases.
Buy Safe, Secure Tickets from Ticketmaster
49ers fans can buy, sell and transfer their game tickets safely and securely viaTicketmaster, the Official Ticketing Partner of the San Francisco 49ers and Levi's Stadium. Fans can rest assured that tickets purchased from official sources like Ticketmaster, the San Francisco 49ers website and Visa Box Office are completely safe and secure.
Levi's Stadium Mobile Ticketing
As a reminder, Levi's Stadium exclusively features mobile ticketing for all 49ers games. Fans may manage game tickets and parking directly from a mobile device or personal computer. The easiest way to manage your tickets is through the 49ers app available on iOS and Android. Fans can scan tickets or parking passes for entry, or access tickets to forward onto a friend or coworker for use. Fans may also access or manage their tickets by logging into their account at49ers.com/myaccount. Management of season tickets is currently available for accounts that are fully paid for the 2025 season. As a continuing benefit, Season Ticket Members will have access to popular food and beverage items at no additional charge through the Member Inclusive Menu, presented by Ticketmaster.
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