With the Carolina Panthers starting the 2022 season with a pair of losses, Matt Rhule has regained his favorite status as the first NFL coach likely to be fired.

Rhule topped the list over the offseason but was temporarily surpassed by Mike McCarthy after Dallas lost its season opener along with quarterback Dak Prescott to an injury.

The Cowboys rebounded with a Week 2 victory over the reigning AFC champion Cincinnati Bengals, and Prescott is on an accelerated path to returning. Meanwhile, the Panthers lost at the New York Giants last week and the offense is sputtering with new quarterback Baker Mayfield.

Rhule is now the 200 favorite at SportsBetting.ag to be the first head coach fired this season. His fate could be determined by how the Panthers' upcoming three-game homestand goes against New Orleans, Arizona and San Francisco.

Indianapolis' Frank Reich is feeling the heat of an 0-1-1 start after the Colts acquired veteran quarterback Matt Ryan. Reich opened the week at 350 but his odds had lengthened to 700 at the sportsbook by Thursday.

Reich was surpassed by Denver's Nathaniel Hackett, who has the second-shortest odds at 500 despite being only two games into his tenure. The Broncos' first-year coach opened the week as a 2000 longshot in the prop market but has come under intense scrutiny for poor clock management during an opening loss at Seattle and a come-from-behind win at home against Houston.

Arizona's Kliff Kingsbury might have received a bit of a reprieve with the Cardinals storming from behind to win in Las Vegas after a home blowout loss to Kansas City in Week 1. Kingsbury's odds of being the first coach fired are 800.

First NFL Coach Fired/Resign Odds:

Matt Rhule, 200

Nathaniel Hackett, 500

Frank Reich, 700

Kliff Kingsbury, 800

Mike Vrabel, 1000

Josh McDaniels, 1200

Kevin Stefanski, 1200

Ron Rivera, 1400

Mike McCarthy, 1600

Arthur Smith, 2000

Pete Carroll, 2000

Lovie Smith, 3300

Dennis Allen, 4000

Dan Campbell, 4000

Robert Saleh, 4000

Zac Taylor, 4000

Mike Tomlin, 4000

John Harbaugh, 5000

Kyle Shanahan, 5000

Matt Eberflus, 6600